Vagus nerve stimulation for epilepsy: A review of the peripheral mechanisms

Vagus nerve stimulation for epilepsy: a review

Vagus nerve stimulation is an empirically based method for treatment of epilepsy by repeated stimulation of the left vagus nerve through implanted electrodes. Despite studies in animals and man, which show changes in brain electrophysiology, metabolism and neurochemistry, the mode of action remains unknown. Clinical testing has presented methodological challenges, as it is difficult to assess u...

Mechanisms of Vagus Nerve Stimulation for Epilepsy and Associated Comorbidities

While the efficacy of vagus nerve stimulation (VNS) to reduce seizures and improve comorbidities associated with pharmacoresistant epilepsy including mood as well as quality of life is clinically proven, the exact mechanism of VNS remains unclear. VNS exerts antiepileptic or anti-epileptogenic effect possibly through i) neuromodulation of release of noradrenaline from locus coeruleus; ii) induc...

Assessment of Vagus Nerve Stimulation for Epilepsy

Introduction and methodology. Despite a recent surge in availability of new antiepileptic medications and advances in surgical therapy for epilepsy, intractable epilepsy remains a very significant problem. At least 25 to 50% of patients with epilepsy suffer from breakthrough seizures or debilitating side effects of medications. We need a safe and effective treatment for these people, even if it...

Reassessment: vagus nerve stimulation for epilepsy.

A July 1997 assessment of the American Academy of Neurology (AAN) Therapeutics and Technology Subcommittee reviewed vagus nerve stimulation (VNS) for epilepsy, and concluded that it was promising, but not yet established. Subsequent to that review, a second multicenter, randomized, controlled clinical trial has shown safety and efficacy of VNS for treatment of intractable partial seizures. Give...

Vagus Nerve Stimulation Therapy for Epilepsy